By Development, and Translation Forum on Drug Discovery, Institute of Medicine

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Snodgrass also expressed concern that pediatricians lack a good evidence-based reference for making prescription decisions. For example, there is disagreement on whether dosing should be based on weight or surface area. Dr. Snodgrass further suggested that dissemination of information to physicians could be improved so they can make the best choices in prescribing medications for individual patients. Finally, Dr. Snodgrass and others seconded Dr. Giacoia’s emphasis on the importance of the taste and formulation of a drug to adherence in pediatric patients—more so than is the case with adults.

Natasha D. Jarrett graduated from Oxford Brookes University with an honors degree in biology and has worked in regulatory affairs since 1997. Ms. Jarrett started her regulatory career at GlaxoWellcome, UK and subsequently moved to Hoffmann-La Roche in Hertfordshire, UK, where she worked on a range of local marketing and development projects. For the past 4 years, Ms. S.

This section is based on the presentation of Dr. Evans. MODELS FOR ENHANCING PEDIATRIC DRUG DEVELOPMENT 35 Dr. Evans and others convened a group of doctors and scientists to create a scientific plan that would clearly outline what needed to be done to develop new drugs for pediatric cancers. The effort involved partnerships with academia, large and small pharmaceutical companies, government health agencies, and philanthropic foundations. St. Jude Children’s Research Hospital has focused on filling the gap in the discovery of pediatric cancer drugs by building a Good Manufacturing Practices (GMP) facility, and launching a Chemical Biology and Therapeutics initiative.

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