By Jerome Pine (auth.), Makoto Taketani, Michel Baudry (eds.)

This publication booklet is an try and assessment the new development in either electronics and computational instruments constructed to investigate the useful operations of huge ensembles of neurons and to supply the readers with a feeling of the functions made attainable by way of those technological instruments. whereas huge development has been revamped the final many years in our knowing of electrophysiological approaches on the unmarried channel, single

synapse, and unmarried neuron degrees, our knowing of electrophysiological

processes on the neuronal community point continues to be in its infancy.

This ebook includes:

  • Technological overviews of multi-electrode arrays (MEAs) and similar electronics and software,
  • Applications of MEAs to check ensemble job of dissociated mobile cultures together with cardiac myocytes,
  • Applications of the expertise for drug discovery utilizing acute and cultured slices.

Examples of stories directed at figuring out the origins and services of assorted rhythmic actions in neuronal ensembles.

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Extra resources for Advances in Network Electrophysiology: Using Multi-Electrode Arrays

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Thus the chip can be easily mounted in an industry standard socket holder. 5. A high-density MEA is wire-bonded to a standard IC socket commonly used in personal computers. The layout of the high-density HD-MEA is shown on the right. 2. 6. A MEA with holes in the substrate. The ring enclosing the actual MEA field consists of perfusion holes with 50-µm diameter. The openings in between the MEA electrodes are 20 µm in diameter and negative pressure enhances the contact of the tissue onto the substrate.

1988). Multisite hippocampal slice recording and stimulation using a 32 element microelectrode array. J. Neurosci. Meth. 23: 149–159. , and Taketani, M. (1999). A new planar multielectrode array for extracellular recording: Application to hippocampal acute slice. J. Neurosci. Meth. 93: 61–67. P. , and Meister, M. (2003). Segregation of object and background motion in the retina. Nature 423: 401–408. Pine, J. (1980). Recording action potentials from cultured neurons with extracellular microcircuit electrodes.

Additionally, the openings can be used to perfuse the slice from the bottom side. 3 The MEA60 System The MEA60 System was originally introduced in 1996 by Multi Channel Systems (MCS) and many researchers throughout the world are using the system with a variety of biological preparations and for diverse applications. For a more detailed description and applications with the MEA60 system we refer to various chapters in this book. com). The 60-channel amplifier has a compact design (165 × 165 × 19 mm), and due to the surface-mounted technology (SMD) of pre- and filter amplifiers the complete 32 Michael Fejtl et al.

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