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P h i l i p s o n , J. Clin. Pharmacol, 8 ( 3 ) , 180 (1968). 5. M. A. Schwartz, F. M. Vane and E. Fostma, J. Med. Chem. 2 ( 4 ) , 770 (1968). 6. L. H. Sternbach, G. A. Archer, J. V. Earley, R. I . Fryer, E. Reeder, N. Wasyliw, L. 0. Randall and R. Banziger, J. Med. Chem. 8, 815 (1965). 7. H. J i c k , Current Therap. Res. 9, 355 (1967). 2-(1968). 8. FDC Reports, 30(12), T 81 G 820 (1967). 9. A. J. A r i e f f and N. Wetzel, Diseases Nervous System =(12), 10. H. L. Yale, J. Med. Chem. 11(2), 396 (1968).

4e b u t was n o t compatible w i t h epinephrine and produced poor a n n g e s i a . 4e when t h e drug was given w i t h n i t r o u s oxide-oxygen t o 100 p a t i e x s i n d i c a t e d t h a t i t deserved f u r t h e r c l i n i c a l evaluation. Chap. 3 D epr e s sant s 35 Lun sfor d References 106, 14P (1968). 1. D. R i d d e l l and B. E. Leonard, Biochem. J. 2. B. E. Leonard and D. R i d d e l l , B r i t , J. Pharmacol. 34(3), 659P (1968). 3. A. J. Dietz, Jr. and R. M. Burgison, T o x i c o l .

Meetingt2. The pharmacology of aletarnine Analg eti c s Chap. p. H CH NR 2 2 2 (26) (25) s t x l t u t i o n on t h e p i p e r i d i n e r i n g ( 2 7 , R = C H ) g i v e s more a c t i v e , but mor6 5 p h i n e - l i k e , compounds. CH F 1 2 -- -0COCH 3 COC H 2 5 c2H-0 5 I CHJ$(CH ) 3 2 '6Tetrahydrocannabinol (28) h a s been shown47 t o p o s s e s s about one h a l f t h e a c t i v i t y of morphine i n mice and r a b b i t s u s i n g a v a r i e t y o f t e s t s . The n a t u r e of t h e a n a l g e s i a is s a i d t o d i f f e r from t h a t of morphine and i t is s p e c u l a t e d t h a t t h e compound will induce h a b i t u a t i o n r a t h e r t h a n addiction.

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