By Jean-Louis Vincent (Ed.), Jean-Louis Vincent
The Yearbook compiles the newest advancements in experimental and scientific examine and perform in a single accomplished reference booklet. The chapters are written by way of good well-known specialists within the box of in depth care and emergency medication. it truly is addressed to each person all in favour of inner drugs, anesthesia, surgical procedure, pediatrics, extensive care and emergency medicine.
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Additional info for Annual Update in Intensive Care and Emergency Medicine 2014
From the plasma, iron is mainly transported to the bone marrow, where it is used for the production of new red blood cells. Hepcidin attenuates the release of iron from macrophages, and the uptake of iron from the gut, thereby leading to decreased serum iron levels. Hepcidin is produced in the liver and is induced by increased iron supply and inflammation, whereas it is downregulated by low iron supply, hypoxia and increased erythropoiesis. TfR: transferrin receptor; HJV: hemojuvelin. Adapted from  with permission of the authors 20 L.
Pediatr Crit Care Med 12:494–503 3. Dunser MW, Festic E, Dondorp A et al (2012) Recommendations for sepsis management in resource-limited settings. Intensive Care Med 38:557–574 4. Dellinger RP, Levy MM, Rhodes A et al (2013) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock 2012. Intensive Care Med 39:165–228 5. Plambech MZ, Lurie AI, Ipsen HL (2012) Initial successful implementation of sepsis guidelines in an emergency department. Dan Med J 59:A4545 6.
Moreover, none of these studies has shown a clear adverse effect on infection rates, which is compatible with the notion that the NTBI fraction in particular is important for the risk of infection, whereas this fraction is usually low in iron-deficient patients even after iron treatment. gov identifier NCT01180894). In addition to the lack of clear evidence that iron administration is harmful to the iron-deficient critically ill patient, iron deficiency is also associated with impaired immunity and increased susceptibility to infection, as well as being associated with increased length of stay in the ICU , providing an extra reason to further examine the possible role of iron administration in the setting of intensive care medicine.