By Robert A. Scherrer, Michael Whitehouse

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In "Drug Design" (E. J. ), Vol. 1. pp. 162-193. Academic Press, New York. Ariens, E. , Simonis, A. , and Van Rossum, J. M. (1964). In "MolecularPharmacology" (E. J. ), Vol. 1, p. 287. Academic Press, New York. Bäumer, A. (1971). In "Rheumatoid Arthritis" (W. -G. Harwerth,^ and F. ), pp. 609-618. Academic Press, New York. Berry, P. , and Collier, H. O. J. (1964). Brit. J. Pharmacol Chemother. 23, 201. Black, M. L. (1963). /. Med. Chem. 6, 145. Boissier, J. , Lwolf, J. , and Hertz, F. (1970). Therapie 25, 43.

This topic was recently discussed by Bäumer (1971). Clinical aspects have most recently been reviewed by Lockie (1972). According to the latter author, hydroxychloroquine is the preferred of the two agents. B. Benzydamine Benzydamine (5) is not discussed elsewhere in this volume. Its inclusion at this point serves to emphasize some of the problems in the evaluation of new agents. Benzydamine is available in some countries outside the United States as an antiinflammatory analgesic. It is not a classical nonsteroidal agent (as defined in Section IV of this chapter), nor is it steroidlike, chloroquinelike, or goldlike.

Oesterling, T. , and Roseman, T. J. (1972). J. Pharm. Sei. 61, 1861. Piper, P. , and Vane, J. R. (1969). Nature (London) 223, 29. 2. CHEMISTRY OF ANTIINFLAMMATORY AGENTS 43 Scherrer, R. , Winder, C. , and Short, F. W. (1964). Nat. Med. Symp. Amer. Chem. Soc, Div. Med. , 1964 Abstract, pp. 1 la—1 li. Shen, T. Y. (1965). Int. Symp. Non-Steroidal Anti-Inflammatory Drugs, Proc, 1964 pp. 13-20. Shen, T. Y. (1967). Top. Med. Chem. 1, 29-78. Shen, T. Y. (1972). Angew. , Int. Ed. Engl. 11, 460. Shen, T.

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