By H.P.T. Ammon, H.U. Häring, M. Kellerer, H. Laube, L. Mosthaf, E.J. Verspohl and M.A. Wahl (Eds.)

Quantity 27, the 1st thematic quantity within the sequence, offers an outline of current wisdom in regards to the pharmacological and scientific points of antidiabetic medicinal drugs. It goals to stimulate additional attention of attainable recommendations within the improvement of recent antidiabetic medicinal drugs.

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The originally described 185 kDa protein was, meanwhile, found in many cells. , 1987). , 1988). , 1988a). , 1988). , 1988), becomes phosphorylated in the intact cell. So far, signal transduction with respect to specific insulin effects, has not been demonstrated through any of these proteins except for the 185 kDa protein. , 1991) and demonstrated to function as a docking protein which links the insulin receptor to other signal-transducing elements in the cell. 2 Insulin Receptor Substrate-1 (IRS-1) in Post-kinase Signalling The first evidence of a cellular substrate of the insulin receptor kinase came from White et al.

But as the autoimmune destruction of the B-cells continues, insulin requirements increase again. Some patients may retain a few functioning B-cells with some endogenous insulin production in the long term, thus having better blood glucose control and being less prone to diabetic complications. 3 NATURAL HISTORY AND PROGNOSIS The natural history of the disease is determined by the onset and extent of chronic diabetic complications. Microangiopathic changes are diabetesspecific, causing retinopathy, nephropathy and alterations in the peripheral and autonomous nervous system.

1985b) were the first to use a phosphotyrosine-specific antibody to identify tyrosine-phosphorylated proteins in the intact cell. , 1985b). e. rapid phosphorylation in the intact cell upon stimulation by physiological insulin concentrations. , 1987) in the plasma membrane, both with unknown function. In the cytosol a number of bands were found. The originally described 185 kDa protein was, meanwhile, found in many cells. , 1987). , 1988). , 1988a). , 1988). , 1988), becomes phosphorylated in the intact cell.

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