By Alan Talevi, Luisa Rocha

This thorough quantity delves into antiepileptic drug discovery with a accomplished number of leading edge methods for the improvement of antiepileptic treatments, concentrating on novel molecular goals for antiepileptic medicinal drugs, computer-aided ways for the id of latest drug applicants, and healing options to beat refractory epilepsy. The final part illustrates the capability merits that community pharmacology and rational drug repurposing may well carry to the antiepileptic drug discovery group. Written for the Methods in Pharmacology and Toxicology sequence, chapters comprise the type of specific description and implementation suggestion to make sure ends up in the laboratory.
Authoritative and useful, Antiepileptic Drug Discovery: Novel Approaches goals to supply medicinal chemists, pharmacologists, and different researchers with the instruments have to extra discover the examine of pharmacoresistant epilepsy and the invention of latest antiepileptic drugs.

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26 María Guadalupe Valle-Dorado et al. Different neuroinflammatory processes increase neuronal excitability, which in turn produce an increase in seizures, situation that favors neuroinflammation generating a harmful vicious circle for the organism. This recurring sequence of events may contribute to the development of epilepsy [38]. This is the reason for which the search for pharmacological strategies focused on the pharmacological blockade of pro-inflammatory pathways in the CNS, which may be considered antiepileptic, is relevant [39].

3 Conclusion It is clear that epilepsy is associated with neuroinflammation processes, which in turn induce neuronal damage. For this reason, the use of drugs that facilitate neuroprotection and/or which block transduction cascades associated with neuroinflammation is so relevant. Therefore, the search for combinations of these drugs with traditional antiepileptic drugs may result as a more effective strategy to control epileptic activity and its consequences. Anti-Inflammatory Drugs in Epilepsy 33 Fig.

1: Acetazolamide; 2: Methazolamide; 3: Sulthiame; 4: Topiramate and 5: Zonizamide tested as anticonvulsant (Fig. 3), but it has gained more attention as antiglaucoma drug [29, 41, 42]. Sulthiame is another sulfonamide derivative employed as AED (Fig. 3). It is prescribed to treat partial epilepsy in children in Europe and Australia [43], but serious side effects related with deterioration in cognitive functions have been reported [44]. Topiramate (Topamax®) is a broad spectrum AED employed for the treatment of partial and generalized seizures, including Lennox–Gastaut syndrome and prophylactic treatment of migraine [45, 46].

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