By Ho R.J.Y., Gibaldi M.

To aid scientists and healthcare execs hold velocity with advancements in bioengineered medicines, Ho and Gibaldi (U. of Washington university of Pharmacy, Seattle) introduce monographs on biopharmaceutical applied sciences and tactics, cures according to biotechnology, and destiny instructions (e.g, individualized gene- established medicine)-while acknowledging that biotechnology is anathema to a couple. Appended tables summarize technical info and knowledge on healing use and nomenclature. An auxiliary website is out there.

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In contrast with the postwar strategies of the established drug industry, dedicated biotechnology companies were created to exploit the commercial potential of technological innovation and ideas. Therefore 23 many of the early biotechnology companies were founded with emphasis on science and technology, and were modeled after research organizations and institutions. 1). 4 billions in 2002 [4]. Despite the government’s largesse, the pioneering biotechnology firms survived by commercially exploiting technologic innovations and developing diagnostic tools, rather than by developing novel therapeutic entities.

Sometimes the therapeutic target is obvious and indeed the point of development, but often it is not because many molecules exhibit therapeutic potential in multiple disease targets. 2. 2. 1 Total public companies 301 317 327 Source: Adapted from the Ernst and Young [5]. a Viability as measured by Ernst Young Survival Index, derived from the skew analysis. The estimates are expressed as the number of years of cash that companies have on hand based on current spending levels and on fiscal year-end numbers.

Furthermore the ability of a biotechnology companies to raise funds increases greatly when a biopharmaceutical candidate is in clinical trials. Having a new drug in the clinic for more than one indication gives the company greater leverage to attract venture capital as well as public offerings. The accumulated statistical data on success rate for all new drug candidates committed to clinical testing indicate that only one of four or five agents entering phase I will be approved by the FDA. To increase the chance of success of getting a biopharmaceutical to market, the alternative or newer strategy is to seek more than one indication for a given drug by initiating several clinical studies at about the same time.

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